I am an Adjunct Professor of Research in the Department of Physiology and Pharmacology and an Associate Scientist at the Robarts Research Institute, the Lawson Health Research Institute, and the Brain and Mind Institute at Western University
My current program of research focuses on developing an integrated understanding of the organization, function and age-related vulnerability of the cholinergic system. The projects currently underway in my lab ask the following questions: How can the organization of the brain's cholinergic projections inform our understanding of cortical networks and cognition? How does cholinergic modulation affect cortical activity and encoding? Why are certain cholinergic neurons selectively vulnerable to neurodegenerative diseases of aging, such as Alzheimer's? How do the vulnerabilities of cholinergic neurons influence pre-symptomatic disease trajectories, and how do these trajectories map to clinical symptoms? Finally, how can we better treat cholinergic dysfunction with personalized lifestyle and pharmacological interventions?